Healing Assessment of Osseous Defects after Surgical Removal of Periapical Lesions in the Presence of Hydroxyapatite, Nanohydroxyapatite, and a Combination of Nanohydroxyapatite and Platelet-rich Fibrin: A Clinical Study

Abstract:
 Aim: to evaluate the bone healing in failed endodontically treated teeth after surgical removal of periapical lesions and placement hydroxyapatite (HA), nanohydroxyapatite (nHA) a combination with platelet rich fibrin (PRF) periapically. Subjects methods: study was conducted on twenty-four patients having radiolucency single rooted teeth. The selected were divided into three groups: Group A, B, C; 8 each. All retreated two visits. In first visit old filling removed using Protaper retreatment files (Dentsply Sirona®) then irrigation sodium hypochlorite 2.5% done. canals dried filled Di-antibiotic paste (metronidazole ciprofloxacin). second obturated Pro Taper gutta-percha points root canal sealer (Adseal resin sealer) followed by intervention same day. A curettage along apicoectomy established. all groups, end cavity prepared MTA (ProRoot MTA; DENTSPLY Tulsa Dental Specialties). powder packed curetted defect. C, PRF mixed recall visits scheduled at 1, 3, 6 months’ time intervals for clinical radiological evaluation. Results: one month; there statistically significant difference between median percentage changes size groups. Pair-wise comparisons groups revealed that no group B C (PRF nHA) Both showed significantly higher reduction than (HA group). After as well six months; decreases Conclusion: It concluded nHA produced faster (bone regeneration) months alone. However, HA produce months.